Prevention of systemic toxicity in hyperthermic isolated lung perfusion using radioisotopic leakage monitoring
نویسندگان
چکیده
منابع مشابه
Hyperthermic isolated limb perfusion for extremity sarcomas.
BACKGROUND The treatment options available for extremity sarcomas are amputation or limb-sparing surgery with radiation, which may incur significant morbidity and body disfigurement. Hyperthermic isolated limb perfusion (HILP) may be an attractive option in extremity sarcomas for unresectable lesions to preserve limb function and maintain quality of life. METHODS We report the outcomes of 5 p...
متن کاملSystemic toxicity after isolated limb perfusion with melphalan for melanoma.
Systemic exposure to melphalan is minimized during isolated limb perfusion (ILP) by isolating a limb from the rest of the body. Consequently, there should be no toxicity to vital organs. At present systemic toxicity after ILP has not been studied in detail. Therefore, the incidence, nature and risk factors of systemic toxicity was retrospectively studied in 368 patients who underwent a single I...
متن کاملDesflurane as a marker of limb-to-systemic leak during hyperthermic isolated limb perfusion.
SOME malignancies of the extremities can be treated by hyperthermic isolated limb chemotherapy. This procedure involves arterial and venous cannulation of the affected limb and isolated perfusion using a bypass pump. When a steady state is reached, the blood is warmed and oxygenated, and a chemotherapeutic agent (e.g., melphalan) is added and circulated in the limb for up to 1 h. Because the li...
متن کاملIsolated lung perfusion.
Isolated lung perfusion (ILP) has been historically used as a method to study basic lung physiologic concepts using animal models. More recently, ILP has been applied in lung transplantation and thoracic oncology. In lung transplantation, ILP has been used to assess physiological integrity of donor lungs after the organ is removed from the donor. This procedure is called Ex vivo Lung Perfusion ...
متن کاملIsolated lung perfusion with gemcitabine combined with radiotherapy: no additional lung toxicity in an experimental model.
OBJECTIVES Isolated lung perfusion with gemcitabine is an effective technique for the treatment of lung metastases in an experimental model. In clinical studies, increased toxicity has been observed when combining intravenous gemcitabine with radiotherapy (RT). The goal of our study was to determine whether RT in combination with isolated lung perfusion increases lung toxicity. METHODS Rodent...
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ژورنال
عنوان ژورنال: International Journal of Hyperthermia
سال: 2017
ISSN: 0265-6736,1464-5157
DOI: 10.1080/02656736.2017.1355485